Rev. Reuben E. Ezemadu is the founding (and currently the International) Director of the Christian Missionary Foundation Inc. with about 383 missionaries in Nigeria and  nine other countries in Africa and beyond. He has also served as the pioneer General Secretary and later as the Chairman of NEMA (Nigeria Evangelical Missionary Association) from 1983 until 1995. He served on the WEA Missions Commission during his tenures as General Secretary and Chairman of NEMA. In addition, he served as the General Coordinator of the Third World Missions Association (TWMA) for ten years. Currently he is the CONTINENTAL COORDINATOR of the MOVEMENT FOR AFRICAN NATIONAL INITIATIVES (MANI) after serving as the National Coordinator of NIGERIAN FINISH THE TASK NETWORK (NIGERIA FINTASK) and the Anglophone West Africa Coordinator of the Movement for African National Initiatives (MANI) (both former AD 2000 & Beyond Movement offshoots) and Co-Convenor of the Issue Group on Two Thirds World Church in 2004 Lausanne World Forum on Evangelization. He served on the International Facilitating Team of the Great Commission Roundtable (GCR)  that was created after the phasing out of the AD 2000 Movement as well as the Nigeria Ministry Center Director of the Development Associates International (DAI).

He is married to Mrs. Bosede Olaitan Ezemadu and blessed with four children (Chika, Chuks, Buchi and Joshua) and a grand-daughter (Chinwe).